Justin Martyr c. 100–c. 165 ADDialogue with Trypho 71.1–2
I do not trust your teachers, who refuse to admit that the translation made by the seventy elders at the court of Ptolemy, king of Egypt, is correct, and try to make their own. I want you to know that they have entirely removed many passages from the translation made by the elders at Ptolemy's court, passages that show plainly that this very man who was crucified was proclaimed as God and man, crucified and dying.
By the second century Jewish scholars made new Greek translations (Aquila and others). Christians held to the older Septuagint, especially for Isaiah 7:14, "the virgin shall conceive".